In this paper we introduce the Scientific Cooperation Portal (SCP), a social enterprise software, and how it is integrated into our process of Scientific Cooperation Engineering. This process is applied in a large-scale interdisciplinary research cluster to ensure and manage the success of the interdisciplinary cooperation of over 180 researchers in different qualification levels. We investigate the influence of shared method competencies as an exemplary driver for collaboration. From the results we address both offline and online measures to improve interdisciplinary collaboration. We show how the knowledge generated from offline measures such as colloquia are transferred to the SCP and connected with other data available on the portal. This includes the handling of interdisciplinary terminologies, the disposability of publications and technology data sheets. The portal fosters knowledge exchange, and interdisciplinary awareness within the research cluster as well as technology dissemination both within the cluster, across the university, and into industry. The effectiveness of the approach is continuously assessed using a traditional balanced scorecard approach as well as additional qualitative measures such as interviews and focus groups.